This is what MT-CONNECT and MedTech Summit 2018 have to offer.
Surface refinement of implants using plasma technology
In medical engineering, plasma technology has proven its suitability for the generation of biorelevant surface properties of implants. The talk shows the capability of plasma-based processes to tailor the cell-biomaterial interface. Results on the surface modification of metals and polymers as well as an outlook for future applications will be presented.
For the integration of an implant or a scaffold for tissue engineering, the rapid acceptance by the surrounding tissue is decisive. Especially the cell-biomaterial interface plays a vital role for the success or the failure of an implant. In particular, surface properties such as roughness, chemical composition and surface charge initiate and influence the cellular response to biomaterials. The objectives are the improvement of adhesion, migration, and proliferation of cells at the interface to i) promote a faster ingrowth, ii) to decrease the infection risk, and iii) to increase the implant’s lifetime. Based on their high chemical reactivity and low gas temperature, physical plasmas are suitable for the application in the medical field, e.g. for the surface modification. By using plasmas, the tailoring of surface properties of different materials such as metals, ceramics, polymers and textiles are feasible in a fast and environmentally friendly way. In the field of endoprosthetics, the plasma technology is used - and has been established for many years - to generate rough titanium surfaces. However, the possibilities for plasma-based surface refinement are quite divers. For instance, surfaces can be enriched with foreign atoms, covered with a monolayer of special molecules or coated with a layer in the micron range. This includes antimicrobial surfaces that provides an inactivation rate of more than 99 % even for multidrug-resistant bacteria over a specific period whereas human bone cells still show a good vitality of about 80 %. Additionally, plasma processes can be used to generate cell-adhesive surfaces that initiate a 3-fold enhanced initial cell adhesion after 5min and a 2-fold increased cell spreading and vitality after 30 min of incubation.
--- Date: 11.04.2018 Time: 10:25 AM - 10:50 AM Location: Hall Brüssel II, NCC Mitte