This is what MT-CONNECT and MedTech Summit 2018 have to offer.
Realizing the Individual – Personalized Concepts in Orthopedic Treatment and Corresponding Biological Testing
In order to account for individual differences of bone and cartialge, different rapid prototyping strategies can create regenerative implants. The adapted biological testing opens the path to patient screening methods as part of an individual orthopedic treatment concept.
No bone in our body is alike another. What’s more, microarchitecture, physiology, mechanical strain and cellular processes differ so much between individuals and even for one individual at different times of life that regenerative processes can occur completely different. The same holds true for cartilage, which doesn’t even exist as one homogeneous type of tissue over more than one joint. In spite of that, all regenerative approaches so far proposed one uniform material as universal solution for each tissue. Even though some parameters might be adapted by self-healing, certain central properties have to be adjusted individually.
Rapid Prototyping is an ideal platform of technologies to realize adapted implants. The very versatile technology of dispense plotting makes it possible to print individual cartilage implants. Resorbable bone substitutes can be additively manufactured with powder-bed printing. Further modifying material composition and structural compatibility with post-processing leads to additional adjustment, revealing interesting effects of microporosity on the invasion and differentiation of osteoblasts, osteoclasts and the development of mesenchymal stem cells in the material. In order to control the suitability of the designed, printed pore channels, sensitive in vitro models are used, with unexpected results.
The construction of sensor-integrated bioreactors that can adapt to single implant geometries made necessary by this opens, on a side-path, a new chapter in individualized medicine. Using standardized scaffolds in pragmatically designed bioreactors, cells from patients can be cultivated and their biological properties extensively studied. A universal screening method for the biological properties of bone and cartilage cells as part of an individualized orthopedic treatment appears close at hand.
--- Date: 11.04.2018 Time: 11:45 AM - 12:10 PM Location: Hall Brüssel II, NCC Mitte